Symptomatic Renal Infarct Secondary to COVID-19 Infection and Concomitantly Positive Antiphospholipid Antibody

COVID-19 infection predisposes patients to a hypercoagulable state. The clinical significance of concomitantly positive antiphospholipid antibodies as a risk factor for thrombus formation is unknown. We report a case of renal infarct secondary to COVID-19 infection with mildly elevated antiphospholipid antibodies. A 71-year- old woman with a history of hypertension, supraventricular tachycardia, resected carcinoid tumor in remission, COVID-19 infection (20 days prior), presented to the hospital with acute onset severe left lower quadrant pain radiating to the left flank for one day. She reported a fever of 101 F. Vital signs were normal in the emergency room. Physical exam showed left costovertebral angle tenderness, otherwise benign abdomen with no guarding or rigidity. Laboratory findings showed normal liver function tests, mildly elevated creatinine at 1.1 mg/dl (baseline 0.8 mg/dl), and leukocytosis (14.2 K/ul). Urinalysis showed no evidence of proteinuria or microscopic hematuria. CT scan of the abdomen demonstrated a large area of patchy hypoattenuation involving the upper pole and interpolar region of the left kidney with adjacent perinephric inflammation representing a sequela of an infarct. Hypercoagulable workup including HIV, hepatitis, ANA, ANCA, complements, B2 glycoprotein, homocysteine, factor V Leiden, anti-thrombin III, protein C, protein S were done. All tests resulted negative except for mildly elevated anticardiolipin antibody, IgM 12.90 MPL (normal 0.00-12.49 MPL). Holter monitor was negative for atrial fibrillation. An echocardiogram did not show any thrombus. Considering her negative tests, renal infarct was believed to be secondary to a hypercoagulable state from COVID-19 infection. Antiphospholipid antibodies repeated 3 months after this admission were mildly elevated. Renal infarction was treated with a heparin infusion and was subsequently transitioned to apixaban. Acute kidney injury resolved with intravenous fluid resuscitation. At a 3-month follow-up, her renal function remained stable with a resolution of symptoms. Renal artery infarct is a possible thrombotic complication of COVID -19. Role of lupus anticoagulant antibodies in increasing this risk warrants further studies.

COVID-19 in kidney transplant recipients

Background: Coronavirus disease 2019 (COVID-19) is caused by Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2). Kidney transplant recipients are at a higher risk for complications due to comorbid conditions and concurrent immunosuppression. We like to describe a small cohort of kidney transplant recipients with COVID-19 Methods: A single-center, retrospective observational cohort study describing short term outcomes of COVID-19 infection in kidney transplant recipients. Results: A total of 8 kidney transplant recipients were diagnosed with COVID-19 with a mean age of 58 yrs (26-78), predominantly African American (7/8), mean durationfrom transplant 3.5 yrs (1.5-11 yrs). All patients have HTN (8/8), half the patients have Diabetes mellitus-2 (4/8). Common presenting symptoms are fever and shortness of breath. 6/8 patients required hospitalization. 8/8 patients were managed with a reduction of immunosuppression, primarily by decreasing the dose or holding the anti-proliferative agent. 1/8 patients died, 4/6 discharged from hospital, 1/6 still admitted to the hospital with respiratory failure. 5/6 patients required supplemental oxygen. 2/6 patients required ICU stay and 1/6 required mechanical ventilation and renal replacement therapy. 3/6 hospitalized patients received hydroxychloroquine/ Azithromycin combination and 1/6 received Remdesivir. Median hospital stay is 5 days with a mean of 9 days. The patient who required mechanical ventilation and renal replacement is the only recipient who died from COVID-19 at our transplant center. Conclusions: COVID-19 is a novel infection primarily presenting with fever and shortness of breath. The course of illness appears to be severe with the majority of patients requiring supplemental oxygen and a third of hospital admitted patients required ICU stay. Reduction of immunosuppression appears to be helpful, however, no control group available. COVID-19 affected population is predominantly African American (7/8) and older recipients with age > 50 yrs (7/8).